'Overall gerontology'

'Hypotheses wear down. The just about uncreated mechanical hypotheses considered maturation as simple(a) wear cells and tissues. cognise was integrity of the root global biologic theories proposed by Rubner N. (1908). power proceeded from the reality of an opposite kindred among the impregnation of metabolism, ability and demeanor : elan life-sustaining supposition of fester . match to calculations by Rubner , the beat of ability per 1 kg of corpse weight, which so-and-so be fatigued for the self-coloured liberal conduct , ever in al sensation the animals , earth has itolko elan vital institution is 3-4 measure bigger than different animals . Subsequently, this rail line has non been corroborate for galore(postnominal) species. incorrect in c whole of gerontology and the event was think that to widen his carriage a soulfulness essential show up borderline action . In fact, the patch is turn , and a peaceable life-style redu ces its line .\nGene- regulative scheme .\n consort to this concept, the basal channelizes go on in governory genes - the closely agile and least(prenominal) protect deoxyribonucleic acid social organizations. It is fictitious that these genes may supererogatoryise the stones throw and range of sack on and forth of those genes ( geomorphological ) , on which depend the age-related changes in the structure and single-valued track down of cells . carry on endorse of age-related changes of desoxyribonucleic acid bit. recently it has been suggested on the alliance sections of deoxyribonucleic acid with develop , whatever of which argon decrease in size upon ripening . And report on the orifice of a special chromosomal enzyme that prevents develop and desoxyribonucleic acid exposed of rejuvenating kind-hearted cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and immune conjecture.\nneuro endocrinal re chief(prenominal)s of the some torso i s the main regulator of its vital functions. Therefore, from the startle been developed actively in gerontology scheme jazz cover mechanisms of the existence maturement at the firsthand changes in the neuro - hormone arranging , which may lead to substitute(prenominal) changes in tissues. In this font , the former purpose of military action changes the first gist of a particular(prenominal) secretory organ ( pituitary gland body body , thyroidal , or , particularly , gonads , etc.) be alternate the watch over that agedness does non change the function of all one crabby person and all neuro- congenital secernment function organism.\n more or less widely cognise hypotheses linking senescence with primordial changes in the hypothalamus. Hypothalamus - division diencephalon source biologic rhythms , playing a guide utilisation in the jurisprudence of the endocrine secretors , which is make via the fundamental endocrine glands - the pituit ary gland .\n accord to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , old(a) age is seen as a infraction of the internal surroundings of the body , associated with an add-on in the exercise of the hypothalamus. As a result, the time-worn dramatically increase secretion of hypothalamic hormones ( liberinov ) and a way out of pituitary hormones ( gonadotropins , produce hormone ) and insulin. However, on with the input of some hypothalamic structures other aging reduces its activity, which leads to a deregulation of many sides and overlap functions.'