Single Nucleotide Polymorphism and Breast Cancer

Available online http:// chest-cancer-research.com/ sum/8/4/108 Commentary soar upwards nucleotide polymorphisms and breast cancer: non yet a succeeder story Rulla M Tamimi Channing Laboratory, surgical incision of Medicine, Brigham and Womens Hospital and Harvard Medical School, and De disassemblement of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA match author: Rulla Tamimi, rulla.tamimi@channing.harvard.edu Published: 27 July 2006 This article is online at http://breast-cancer-research.com/content/8/4/108 © 2006 BioMed Central Ltd Breast Cancer look into 2006, 8:108 (doi:10.1186/bcr1529) Abstract chromosomal mutation and its impact on breast cancer systematically. Numerous studies study examined first base penetrance susceptibility polymorphisms in vista genes, with some reporting crucial findings. However, for the most part these connectives could not be replicated in later(prenominal) studies, suggestin g that the master observations were due to chance [5]. In a pooled analysis of 46 tie-in studies examining polymorphisms in 18 different genes, only triple polymorphisms were significantly associated with breast cancer [5]. Despite considerable efforts do during the other(prenominal) few years to study genetic variation and breast cancer, on that point has been little success in identifying authorized contributions to breast cancer. The inadequacy of robust and consistent findings from single SNP association studies led to the effusion of haplotype studies, which promised to examine more comprehensively the association between harsh genetic variation in nominee genes and risk for disease. This latest direction of research efforts has also been moderately disappointing. Numerous studies have examined low penetrance susceptibility polymorphisms in candidate genes, with some reporting significant findings. However, for the most part these associations could not be replicated in subsequent studies, s! uggesting that the original...If you want to get a full essay, order it on our website: OrderEssay.net

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